Aplastic anemia causes: Difference between revisions
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==Overview== | ==Overview== | ||
More than half of the cases of aplastic anemia are idiopathic. Chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated in the other cases. | |||
==Causes== | ==Causes== | ||
One known cause is an [[autoimmune disorder]], where the [[white blood cell]]s attack the bone marrow. | One known cause is an [[autoimmune disorder]], where the [[white blood cell]]s attack the bone marrow. | ||
Revision as of 13:10, 23 September 2012
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Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
More than half of the cases of aplastic anemia are idiopathic. Chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated in the other cases.
Causes
One known cause is an autoimmune disorder, where the white blood cells attack the bone marrow.
In many cases, the etiology is impossible to determine, but aplastic anemia is sometimes associated with exposure to substances such as benzene, radiation, or to the use of certain drugs, including chloramphenicol, carbamazepine, phenytoin, quinine, and phenylbutazone. Many drugs are associated with aplasia mainly in the base of case reports but at a very low probability, As an example, chloramphenicol treatment is followed by aplasia in less than 1 in 40,000 treatment courses,and carbamazepine aplasia is even more rare.
Aplastic anaemia is present in up to 2% of patients with acute viral hepatitis.