Aplastic anemia history and symptoms: Difference between revisions
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, Dearani JA et al.| title=ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report ...) |
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...) |
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==='''[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class III]]'''=== | ==='''[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class III]]'''=== | ||
Diagnosis/Evaluation | |||
Careful history and clinical examination | |||
Detailed drug and occupational exposure history | |||
Patients presenting with aplastic anaemia should be assessed to: | |||
Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow | |||
Classify the disease severity using standard blood and bone marrow criteria | |||
Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones | |||
Exclude a possible late onset inherited bone marrow failure disorder | |||
Multidisciplinary approach | |||
Referral to specialist if necessary | |||
}} | }} | ||
Revision as of 14:23, 23 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Aplastic anemia is seen as a result of hypoplastic bone marrow causing pancytopenia (anemia, neutropenia, thrombocytopenia). The history and symptoms seen are secondary to these abnormalities.
Symptoms
- Malaise, fatigue, and pallor (Anemia)
- Increased risk of hemorrhage, bruising, and menorrhagia (thrombocytopenia).
- Increased risk of infection (leukopenia)
Diagnosis and management of aplastic anemia [1] (DONOT EDIT)
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Class IIIDiagnosis/Evaluation Careful history and clinical examination Detailed drug and occupational exposure history Patients presenting with aplastic anaemia should be assessed to: Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow Classify the disease severity using standard blood and bone marrow criteria Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones Exclude a possible late onset inherited bone marrow failure disorder Multidisciplinary approach Referral to specialist if necessary |
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For ACC/AHA Level of evidence and classes click here.
References
- ↑ Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.