Aplastic anemia medical therapy: Difference between revisions
(/* Specific Treatment of Aplastic Anaemia: Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosi...) |
(/* Specific Treatment of Aplastic Anaemia: Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosi...) |
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* There is no indication for using irradiation-based conditioning regimens for patients undergoing HLA-identical sibling BMT for aplastic anaemia. | * There is no indication for using irradiation-based conditioning regimens for patients undergoing HLA-identical sibling BMT for aplastic anaemia. | ||
* The recommended source of stem cells for transplantation in aplastic anaemia is bone marrow. | * The recommended source of stem cells for transplantation in aplastic anaemia is bone marrow. | ||
* Fertility is well preserved after high dose cyclophosphamide conditioning in BMT for aplastic anaemia, and patients should be given appropriate contraceptive advice to prevent unwanted pregnancy. Until longer term data is available in patients receiving fludarabine-based regimens, cryopreservation of sperm and oocytes should be planned. | * Fertility is well preserved after high dose [[cyclophosphamide]] conditioning in BMT for [[aplastic anaemia]], and patients should be given appropriate contraceptive advice to prevent unwanted pregnancy. Until longer term data is available in patients receiving [[fludarabine]]-based regimens, [[cryopreservation]] of sperm and oocytes should be planned. | ||
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Revision as of 15:24, 23 September 2012
Aplastic anemia Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Aplastic anemia medical therapy On the Web |
American Roentgen Ray Society Images of Aplastic anemia medical therapy |
Risk calculators and risk factors for Aplastic anemia medical therapy |
Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
Medical therapy of aplastic anemia often includes a short course of anti-thymocyte globulin (ATG or anti-lymphocyte globulin) and several months of treatment with cyclosporin to modulate the immune system. Mild chemotherapy with agents such as cyclophosphamide and vincristine may also be effective. Antibodies therapy, such as ATG, targets T-cells, which are believed to attack the bone marrow. Steroids are generally ineffective.
Medical Therapy
Supportive Care in treatment of aplastic anemia [1] (DONOT EDIT)
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Supportive Care
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Specific Treatment of Aplastic Anaemia: General Comments [1] (DONOT EDIT)
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General Comments
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Specific Treatment of Aplastic Anaemia: Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation [1] (DONOT EDIT)
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Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation
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References
- ↑ 1.0 1.1 1.2 Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.