Capillary leak syndrome overview: Difference between revisions
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==Overview== | ==Overview== | ||
Capillary leak syndrome is a rare medical condition characterized by self-reversing episodes during which the [[endothelial]] cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the [[circulatory system]] to the interstitial space, resulting in a dangerous [[hypotension]], hemoconcentration, and [[hypoalbuminemia]]. It is a life-threatening illness because each episode has the potential to cause damage to, or the failure of, vital organs due to limited [[perfusion]]. It is often misdiagnosed as [[polycythemia]], [[polycythemia vera]] or [[sepsis]]. | Capillary leak syndrome is a rare medical condition characterized by self-reversing episodes during which the [[endothelial]] cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the [[circulatory system]] to the interstitial space, resulting in a dangerous [[hypotension]], hemoconcentration, and [[hypoalbuminemia]]. It is a life-threatening illness because each episode has the potential to cause damage to, or the failure of, vital organs due to limited [[perfusion]]. It is often misdiagnosed as [[polycythemia]], [[polycythemia vera]] or [[sepsis]]. | ||
==Historical Perspective== | |||
The [[syndrome]] was first described by B. Clarkson in 1960,<ref name="clarkson">{{cite journal |doi=10.1016/0002-9343(60)90018-8 |title=Cyclical edema and shock due to increased capillary permeability |year=1960 |last1=Clarkson |first1=Bayard |last2=Thompson |first2=David |last3=Horwith |first3=Melvin |last4=Luckey |first4=E.Hugh |journal=The American Journal of Medicine |volume=29 |issue=2 |pmid=13693909 |pages=193–216}}</ref> after whom it was later informally named. Beyond numerous case reports published since then, two comprehensive reviews of clinical and research experience were published in 2010.<ref name="druey">{{cite journal |first1=Kirk M. |last1=Druey |first2=Philip R. |last2=Greipp |title=Narrative Review: Clarkson Disease-Systemic Capillary Leak Syndrome |journal=Annals of Internal Medicine |pmid=20643990 |pages=90–8 |doi=10.1059/0003-4819-153-2-201007200-00005 |pmc=3017349 |year=2010 |volume=153 |issue=2}}</ref><ref name="kapoor">{{cite journal |pages=905–12 |doi=10.4065/mcp.2010.0159 |pmc=2947962 |title=Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience |year=2010 |last1=Kapoor |first1=Prashant |last2=Greipp |first2=Patricia T. |last3=Schaefer |first3=Eric W. |last4=Mandrekar |first4=Sumithra J. |last5=Kamal |first5=Arif H. |last6=Gonzalez-Paz |first6=Natalia C. |last7=Kumar |first7=Shaji |last8=Greipp |first8=Philip R. |journal=Mayo Clinic Proceedings |volume=85 |issue=10 |pmid=20634497}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 20:20, 28 January 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Capillary leak syndrome is a rare medical condition characterized by self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in a dangerous hypotension, hemoconcentration, and hypoalbuminemia. It is a life-threatening illness because each episode has the potential to cause damage to, or the failure of, vital organs due to limited perfusion. It is often misdiagnosed as polycythemia, polycythemia vera or sepsis.
Historical Perspective
The syndrome was first described by B. Clarkson in 1960,[1] after whom it was later informally named. Beyond numerous case reports published since then, two comprehensive reviews of clinical and research experience were published in 2010.[2][3]
References
- ↑ Clarkson, Bayard; Thompson, David; Horwith, Melvin; Luckey, E.Hugh (1960). "Cyclical edema and shock due to increased capillary permeability". The American Journal of Medicine. 29 (2): 193–216. doi:10.1016/0002-9343(60)90018-8. PMID 13693909.
- ↑ Druey, Kirk M.; Greipp, Philip R. (2010). "Narrative Review: Clarkson Disease-Systemic Capillary Leak Syndrome". Annals of Internal Medicine. 153 (2): 90–8. doi:10.1059/0003-4819-153-2-201007200-00005. PMC 3017349. PMID 20643990.
- ↑ Kapoor, Prashant; Greipp, Patricia T.; Schaefer, Eric W.; Mandrekar, Sumithra J.; Kamal, Arif H.; Gonzalez-Paz, Natalia C.; Kumar, Shaji; Greipp, Philip R. (2010). "Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience". Mayo Clinic Proceedings. 85 (10): 905–12. doi:10.4065/mcp.2010.0159. PMC 2947962. PMID 20634497.