HELLP syndrome pathophysiology: Difference between revisions
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==Overview== | |||
The exact cause of HELLP is unknown, but general activation of the coagulation cascade is considered the main underlying problem. Fibrin forms crosslinked networks in the small [[blood vessel]]s. This leads to a [[microangiopathic hemolytic anemia]]: the mesh causes destruction of [[red blood cell]]s as if they were being forced through a strainer. Additionally, [[platelet]]s are consumed. As the [[liver]] appears to be the main site of this process, downstream liver cells suffer [[ischemia]], leading to periportal necrosis. Other organs can be similarly affected. HELLP syndrome leads to a variant form of [[disseminated intravascular coagulation]] (DIC), leading to paradoxical [[hemorrhage|bleeding]], which can make emergency surgery a serious challenge. | The exact cause of HELLP is unknown, but general activation of the coagulation cascade is considered the main underlying problem. Fibrin forms crosslinked networks in the small [[blood vessel]]s. This leads to a [[microangiopathic hemolytic anemia]]: the mesh causes destruction of [[red blood cell]]s as if they were being forced through a strainer. Additionally, [[platelet]]s are consumed. As the [[liver]] appears to be the main site of this process, downstream liver cells suffer [[ischemia]], leading to periportal necrosis. Other organs can be similarly affected. HELLP syndrome leads to a variant form of [[disseminated intravascular coagulation]] (DIC), leading to paradoxical [[hemorrhage|bleeding]], which can make emergency surgery a serious challenge. | ||
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Latest revision as of 14:22, 5 February 2013
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HELLP syndrome Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
The exact cause of HELLP is unknown, but general activation of the coagulation cascade is considered the main underlying problem. Fibrin forms crosslinked networks in the small blood vessels. This leads to a microangiopathic hemolytic anemia: the mesh causes destruction of red blood cells as if they were being forced through a strainer. Additionally, platelets are consumed. As the liver appears to be the main site of this process, downstream liver cells suffer ischemia, leading to periportal necrosis. Other organs can be similarly affected. HELLP syndrome leads to a variant form of disseminated intravascular coagulation (DIC), leading to paradoxical bleeding, which can make emergency surgery a serious challenge.