Hypertensive nephropathy risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]

Risk Factors

• High systolic blood pressure is a very strong risk factor for development of hypertensive nephrosclerosis.
• APOL1 gene
  • This gene has been identified to accelerate the progression of renal disease in African- American hypertensive patients.
• The Framingham heart study showed that a combination of hypertension with mild reduction in glomerular filtration rate was a risk factor for development of chronic renal insufficiency.
• Diabetes, smoking, obesity and high levels of low density lipoproteins also contribute to the progression of renal damage secondary to hypertension.