B-cell lymphoma pathophysiology: Difference between revisions
No edit summary |
|||
| Line 7: | Line 7: | ||
Shown below is a microscopic image of Hodgkins Lymphoma which is a type of B cell lymphoma.Lymph node FNA specimen(Field's stain) | Shown below is a microscopic image of Hodgkins Lymphoma which is a type of B cell lymphoma.Lymph node FNA specimen(Field's stain) | ||
The micrograph shows a mixture of cells commonly seen in Hodgkins lymphoma: | The micrograph shows a mixture of cells commonly seen in Hodgkins lymphoma: | ||
Eosinophils | *Eosinophils | ||
Reed Sternberg cells | *Reed Sternberg cells | ||
Plasma cells | *Plasma cells | ||
Histiocytes | *Histiocytes | ||
[[Image:800px-Hodgkin_lymphoma_cytology_large.jpg|200px]] | [[Image:800px-Hodgkin_lymphoma_cytology_large.jpg|200px]] | ||
Revision as of 19:18, 7 March 2013
|
B-cell lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
B-cell lymphoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of B-cell lymphoma pathophysiology |
|
Risk calculators and risk factors for B-cell lymphoma pathophysiology |
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Pathophysiology
Microscopic Pathology
Shown below is a microscopic image of Hodgkins Lymphoma which is a type of B cell lymphoma.Lymph node FNA specimen(Field's stain) The micrograph shows a mixture of cells commonly seen in Hodgkins lymphoma:
- Eosinophils
- Reed Sternberg cells
- Plasma cells
- Histiocytes
Genetics
Chromosomal translocations involving the immunoglobulin heavy locus (IGH@) is a classic cytogenetic abnormality for many B-cell lymphomas, including follicular lymphoma, mantle cell lymphoma and Burkitt's lymphoma. In these cases, The immunoglobulin heavy locus forms a fusion protein with another protein that has pro-proliferative or anti-apoptotic abilities. The enhancer element of the immunoglobulin heavy locus, which normally functions to make B cells produce massive production of antibodies, now induces massive transcription of the fusion protein, resulting in excessive pro-proliferative or anti-apoptotic effects on the B cells containing the fusion protein. In Burkitt's lymphoma and mantle cell lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1[1] (on chromosome 11), respectively, which gives the fusion protein pro-proliferative ability. In follicular lymphoma, the fused protein is Bcl-2 (on chromosome 18), which gives the fusion protein anti-apoptotic abilities.
References
- ↑ Li JY, Gaillard F, Moreau A; et al. (1999). "Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization". Am. J. Pathol. 154 (5): 1449–52. doi:10.1016/S0002-9440(10)65399-0. PMC 1866594. PMID 10329598. Unknown parameter
|month=ignored (help)