Liposarcoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Common risk factors in the development of liposarcoma include chemical carcinogens, genetic disorders, radiation and immunodeficiency.
Risk factors
Liposarcoma is associated with a number of risk factors. Common risk factors in development of liposarcoma are:
- Chemical carcinogens
- Phenoxyacetic herbicides
- Chlorophenols
- Dioxin contaminations
- Arsenic
- Thorium dioxide (Thorotrast)
- Radiation
- Risk has been found with adjuvant therapy of radiation for breast carcinoma. Risk increases with dose and a dose of 50 GY or more of radiation has been recorded with increased risk of sarcoma. The mean period between exposure to radiation and tumor diagnosis is 10 years.
- Immunodeficiency
- Regional acquired immunodeficiency is sometimes associated with liposarcoma
- Genetic susceptibility
- Li-Fraumeni syndrome
- Neurofibromatosis (NF1; von Recklinghausen disease)
- Gardner syndrome (Familial adenomatous polyposis)
- Retinoblastoma
- Werner syndrome
- Nevoid basal cell carcinoma (Gorlin syndrome)