Neuroblastoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Symptoms of neuroblastoma include fever, abdominal distension, constipation, cough, and weakness.[1][2][3]
History
- When evaluating a patient for neuroblastoma, you should take a detailed history of the presenting symptom (duration, onset, progression), a thorough family history review, and a review of any other associated symptoms. When obtaining the history focus on possible associated syndromes such as:[1]
Symptoms
- General symptoms of neuroblastoma include:
- Fever
- Irritability
- Fatigue
- Loss of appetite
- Weight loss
- However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor:[1][2][3]
- Neuroblastomas located in the abdomen may present with:
- Abdominal pain
- Abdominal distension
- Constipation
- Neurblasotmas located in the posterior mediastinum may present with:
- Metastatic neurblasotma lesions located in the bone marrow may present with:
- Neurblasotmas located in the head and neck may present with:
- Visual changes
- Facial bruising
- Facial swelling
References
- ↑ 1.0 1.1 1.2 Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 7 2015
- ↑ 2.0 2.1 Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015
- ↑ 3.0 3.1 Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.