Esthesioneuroblastoma natural history, complications and prognosis
|
Esthesioneuroblastoma Microchapters | |
|
Diagnosis | |
|---|---|
|
Treatment | |
|
Case Studies | |
|
Esthesioneuroblastoma natural history, complications and prognosis On the Web | |
|
American Roentgen Ray Society Images of Esthesioneuroblastoma natural history, complications and prognosis | |
|
FDA on Esthesioneuroblastoma natural history, complications and prognosis | |
|
CDC on Esthesioneuroblastoma natural history, complications and prognosis | |
|
Esthesioneuroblastoma natural history, complications and prognosis in the news | |
|
Blogs on Esthesioneuroblastoma natural history, complications and prognosis | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Natural History
Esthesioneuroblastoma tumors display varying clinical behaviors ranging from indolent growth to highly aggressive invasion.[1] The average delay between the appearance of the initial symptom and the diagnosis is six months, however diagnosis may be delayed for years in some cases. The delay is predictable because initial symptoms tend to be subtle and are frequently common, occurring also in nasal diseases, including allergic polypoid sinus disease or long-term rhinosinusitis.[2] Despite aggressive therapy, esthesioneuroblastoma has been noted to have a high local recurrence rate of approximately 50–60% with 10–62% presenting as metastatic cases and 20–30% of those cases involving the CNS. Once esthesioneuroblastoma cells invade the cribriform plate, they may spread to the anterior skull base, extend to the leptomeninges or brain parenchyma and can lead to drop metastasis anywhere in central neural axis.[3]
Complications
- Tumor recurrence
- Metastasis[3]
Prognosis
- The majority of studies have found a correlation between Hyams grade and prognosis.[4][5][6][7]
- The prognosis depends on the magnitude of the disease on initial diagnosis.
- Esthesioneuroblastomas often display varying biologic activity ranging from indolent growth, with patient survival exceeding twenty years, to a highly aggressive neoplasm capable of rapid widespread metastasis, with survival limited to a few months.
- CNS metastasis is reported to have a survival expectancy of two years or less and is usually noted 0–10 years after the initial diagnosis.
- Spinal metastasis of ENB is rare with only 28 documented cases involving the spine, spinal cord, or leptomeninges.[8]
- The metastatic rate of esthesioneuroblastoma has been estimated to range from 10 to 62 percent. The most common site of metastatic disease is the cervical lymph nodes but metastatic disease has been found in the parotid, long bones, meninges, breast, lung, prostate, prostate, abdominal viscera, and pelvis.
- The rate of local recurrence for this tumor after therapy is 57% with a survival rate of 56% at the end of five years.
- Prognostic factors must be considered when determining the best treatment for esthesioneuroblasstoma. Murakami et al. reported that histological tumor grade and complete surgical resection are the two most important prognostic factors. Hwang et al. emphasized the importance of diagnosing the disease in an early stage and regular radiologic followups to detect disease recurrence, to improve prognosis.[3]
The relationship between grade of the tumor and ten-year survival is shown below in a tabular form:
| Grade of the tumor | Ten-year survival |
|---|---|
|
|
|
|
The relationshiip between grade of the tumor and five-year survival is shown below in a tabular form:[7]
| Grade of the tumor | Five-year survival |
|---|---|
|
|
|
|
The relationship between metastasis and five-year survival of the tumor is shown below in a tabular form:
| Metastasis | Five-year survival |
|---|---|
|
|
|
|
|
|
References
- ↑ Kane, Ari J., et al. "Posttreatment prognosis of patients with esthesioneuroblastoma: clinical article." Journal of neurosurgery 113.2 (2010): 340-351.
- ↑ Zhang M, Zhou L, Wang DH, Huang WT, Wang SY (2010). "Diagnosis and management of esthesioneuroblastoma". ORL J Otorhinolaryngol Relat Spec. 72 (2): 113–8. doi:10.1159/000278255. PMID 20453548.
- ↑ 3.0 3.1 3.2 Shirzadi, Ali S.; Drazin, Doniel G.; Strickland, Allison S.; Bannykh, Serguei I.; Johnson, J. Patrick (2013). "Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup". Case Reports in Surgery. 2013: 1–8. doi:10.1155/2013/107315. ISSN 2090-6900.
- ↑ Dulguerov P, Calcaterra T (1992). "Esthesioneuroblastoma: the UCLA experience 1970-1990". Laryngoscope. 102 (8): 843–9. PMID 1495347.
- ↑ Kairemo KJ, Jekunen AP, Kestilä MS, Ramsay HA (1998). "Imaging of olfactory neuroblastoma--an analysis of 17 cases". Auris Nasus Larynx. 25 (2): 173–9. PMID 9673731.
- ↑ Hyams, V. J. (1988). Tumors of the upper respiratory tract and ear. Washington, D.C.: Armed Forces Institute of Pathology.
- ↑ 7.0 7.1 Dulguerov P, Allal AS, Calcaterra TC (2001). "Esthesioneuroblastoma: a meta-analysis and review". Lancet Oncol. 2 (11): 683–90. doi:10.1016/S1470-2045(01)00558-7. PMID 11902539.
- ↑ Shaari, Christopher M., et al. "Central nervous system metastases from esthesioneuroblastoma." Otolaryngology--Head and Neck Surgery 114.6 (1996): 808-812.