Hemophilia A historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Hemophilia is sometimes referred to as “The Royal Disease”, as it affected many members of the English, German, Russian and Spanish monarchies in the 19th and 20th centuries.
Historical Perspective
The disease was first described by John Conrad Otto, an American physician, in 1803 based on his observation of affected men in certain families. In 1947, the first distinction between Hemophilia A and Hemophilia B was made by Dr. Alfredo Pavlovsky from Argentina. In 1965, through her work in the coagulation cascade, Dr. Judith Graham Pool discovered that cryoprecipitate left from thawing plasma was rich in Factor VIII. Soon after, the first use of cryoprecipitate to treat hemophilia A was pioneered.