Goodpasture syndrome laboratory findings

Goodpasture syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Goodpasture syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Goodpasture syndrome laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Goodpasture syndrome laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Goodpasture syndrome laboratory findings
CDC on Goodpasture syndrome laboratory findings
Goodpasture syndrome laboratory findings in the news
Blogs on Goodpasture syndrome laboratory findings
Directions to Hospitals Treating Goodpasture syndrome
Risk calculators and risk factors for Goodpasture syndrome laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Laboratory findings consistent with the diagnosis of Goodpasture syndrome include, anti-glomerular basement membrane antibodies elevated blood urea nitrogen, low-grade proteinuria, leukocytosis, gross or microscopic hematuria, and red cell casts.

Laboratory Findings

Laboratory findings consistent with the diagnosis of Goodpasture syndrome include, anti-glomerular basement membrane antibodies, elevated blood urea nitrogen, low-grade proteinuria, leukocytosis, gross or microscopic hematuria, and red cell casts. If laboratory findings do not show anti-glomerular basement membrane antibodies, a test for anti-neutrophil cytoplasmic antibodies should be made to determine possible cause of ANCA associated vasculitis. Routine laboratory test that may be ordered to help in identifying the cause are:

Blood Work-up

• Complete blood count (CBC)
• Uremia
• Serum creatinine
• Blood urea nitrogen (BUN)
• Anti-glomerular basement membrane test
• Anti-neutrophil cytoplasmic antibody test

Urinalysis

• Proteinuria
• Hematuria
• Red cell casts

Renal Biopsy

Renal biopsy is the gold standard in establishing Goodpasture syndrome. As it can help establish the detection of circulating anti-glomerular basement membrane antibodies. It is of note that a renal biopsy is best over a pulmonary biopsy because of abundance of autofluorecene. Renal biopsy reveals early focal proliferative changes that present with necrosis, crescent formation, and inflammation of the interstitial under light microscopy. Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen encompassing the glomerular basement membrane and at times the distal tubular portion.