Androgen insensitivity syndrome classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Classification

Androgen insensitivity syndrome (AIS) represents a spectrum of defects in androgen action and can be subdivided into three broad phenotypes:

• Complete androgen insensitivity syndrome (CAIS), with typical female external genitalia
• Partial androgen insensitivity syndrome (PAIS) with predominantly female, predominantly male, or ambiguous external genitalia
• Mild androgen insensitivity syndrome (MAIS) with typical male external genitalia