Androgen insensitivity syndrome epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Epidemiology and Demographic

Prevalence

• CAIS has aprevalence of 2 per100,000 to 5 per100,000 in otherwise healthy phenotypic females who had histologically normal inguinal or abdominal testes.
• PAIS is at least as common as CAIS.
• MAIS is much less frequently reported than CAIS and PAIS.

Incidence

• The incidence of complete AIS is about in 5 in 100,000. The incidence of milder degrees of androgen resistance might be both more common or less common than CAIS. Evidence suggests many cases of unexplained male infertility may be due to the mildest forms of androgen resistance.
• In netherlands, the minimal incidence was 1 per 99,000 over a ten-year period.