Androgen insensitivity syndrome medical therapy
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Differentiating Androgen insensitivity syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Androgen insensitivity syndrome (AIS) results from androgen receptor dysfunction and is a common cause of disorder of sex development. The AIS phenotype largely depends on the degree of residual androgen receptor (AR) activity. [1]
Medical Therapy
- A multidisciplinary approach is recommended for clinical management from infancy through to adulthood.[1]
- Hormone replacement therapy is needed following gonadectomy.
- Patients who choose to retain the gonads are at risk of developing germ cell tumors for which sensitive circulating tumor markers may soon become available.
References
- ↑ 1.0 1.1 Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA (2015). "Androgen insensitivity syndrome". Best Pract Res Clin Endocrinol Metab. 29 (4): 569–80. doi:10.1016/j.beem.2015.04.005. PMID 26303084.