Bourbon virus infection pathophysiology

	Bourbon virus infection Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
Endosome acidification induces fusion of virus membrane with the vesicle membrane
Encapsidated RNA segments migrate to the nucleus.
Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
Replication of genomic segments.
High level of M1 protein induces genomes segments export from nucleus by NEP protein.
Virus assembly and budding occurs at the plasma membrane.