Bourbon virus infection pathophysiology

Bourbon virus infection Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Pathophysiology

Replication

• Virus attaches to the sialic acid receptors on the host cell through glycoprotein
• The virus gets endocytosed by clathrins into the host cell.
• Endosome acidification induces fusion of virus membrane with the vesicle membrane.
• Encapsidated RNA segments migrate to the nucleus.
• Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
• Replication of genomic segments.
• High level of M1 protein induces genomes segments export from nucleus by NEP protein.
• Virus assembly and budding occurs at the plasma membrane.