The protein encoded by this gene is a receptor tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.[1]
Clinical significance
Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.[1]
↑Masiakowski P, Carroll RD (December 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". J. Biol. Chem. 267 (36): 26181–90. PMID1334494.
↑Oldridge M, Fortuna AM, Maringa M, Propping P, Mansour S, Pollitt C, DeChiara TM, Kimble RB, Valenzuela DM, Yancopoulos GD, Wilkie AO (March 2000). "Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B". Nat. Genet. 24 (3): 275–8. doi:10.1038/73495. PMID10700182.
Further reading
Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID19851296.
Schwarzer W, Witte F, Rajab A, et al. (2009). "A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes". Hum. Mol. Genet. 18 (21): 4013–21. doi:10.1093/hmg/ddp345. PMID19640924.
Forsman M, Pääkkönen V, Tjäderhane L, et al. (2008). "The expression of myoglobin and ROR2 protein in Dupuytren's disease". J. Surg. Res. 146 (2): 271–5. doi:10.1016/j.jss.2007.06.022. PMID17996904.
Sammar M, Sieber C, Knaus P (2009). "Biochemical and functional characterization of the Ror2/BRIb receptor complex". Biochem. Biophys. Res. Commun. 381 (1): 1–6. doi:10.1016/j.bbrc.2008.12.162. PMID19135982.
Brunetti-Pierri N, Del Gaudio D, Peters H, et al. (2008). "Robinow syndrome: phenotypic variability in a family with a novel intragenic ROR2 mutation". Am. J. Med. Genet. A. 146A (21): 2804–9. doi:10.1002/ajmg.a.32530. PMID18831060.
Pacheco II, Macleod RJ (2008). "CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia". Am. J. Physiol. Gastrointest. Liver Physiol. 295 (4): G748–59. doi:10.1152/ajpgi.00560.2007. PMID18703641.
Yoshida T, Kato K, Yokoi K, et al. (2009). "Association of gene polymorphisms with chronic kidney disease in Japanese individuals". Int. J. Mol. Med. 24 (4): 539–47. doi:10.3892/ijmm_00000263. PMID19724895.
Kjaer KW, Tiner M, Cingoz S, et al. (2009). "A novel subtype of distal symphalangism affecting only the 4th finger". Am. J. Med. Genet. A. 149A (7): 1571–3. doi:10.1002/ajmg.a.32905. PMID19533773.
Lv D, Luo Y, Yang W, et al. (2009). "A novel single-base deletion in ROR2 causes atypical brachydactyly type B1 with cutaneous syndactyly in a large Chinese family". J. Hum. Genet. 54 (7): 422–5. doi:10.1038/jhg.2009.48. PMID19461659.
Yoshida T, Kato K, Yokoi K, et al. (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID20198315.
