VIPoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma.[1][2][3][4]
Symptoms
Symptoms of VIPoma may include any of the following:[1][2][3][4]
- Watery diarrhea like cholera and volume ranges from 750ml to more than 3 liters. Secretory diarrhea persists even on fasting for 48hours and is odorless. The stool appears like dilute tea in color.[5]
- Dehydration (thirst, dry skin, dry mouth, tiredness, headaches, and dizziness)
- Lethargy
- Muscle weakness
- Nausea
- Vomiting
- Crampy abdominal pain
- Weight loss
- Numbness caused due to hypokalaemia
- Flushing
References
- ↑ 1.0 1.1 VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm
- ↑ 2.0 2.1 Remme CA, de Groot GH, Schrijver G (2006). "Diagnosis and treatment of VIPoma in a female patient". Eur J Gastroenterol Hepatol. 18 (1): 93–9. PMID 16357627.
- ↑ 3.0 3.1 Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ (2008). "Pancreatic VIPomas: subject review and one institutional experience". J Gastrointest Surg. 12 (2): 382–93. doi:10.1007/s11605-007-0177-0. PMID 17510774.
- ↑ 4.0 4.1 Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
- ↑ Vasoactive Intestinal Peptide Tumor (VIPoma) Aaron Vinik, MD, PhD, FCP, MACP, FACE Murray Waitzer Endowed Chair for Diabetes Research, Professor of Medicine/Pathology/Neurobiology, Director of Research and Neuroendocrine Unit, Division of Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA