Familial adenomatous polyposis screening
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Familial adenomatous polyposis Microchapters |
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Differentiating Familial adenomatous polyposis from other Diseases |
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Risk calculators and risk factors for Familial adenomatous polyposis screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Screening for familial adenomatous polyposis by genetic testing and/or colonoscopy is recommended among patients with history of multiple colonic adenomas and family history of familial adenomatous polyposis.
Screening
Screening for familial adenomatous polyposis for individuals at high risk is done by:[1]
- Sigmoidoscopy every 2 years beginning at age of 10
- Colonoscopy every year following finding adenoma
- If there is a positive family history of familial adenomatous polyposis, screening colonoscopy must be started at the age of the youngest family member's polyps or symptoms.
- Genetic testing
- Colonoscopy every 1 to 2 years beginning at age 10 to 12
- Esophagogastroduodenoscopy (EGD) by age 25 years or prior to colectomy and repeated every 1–3 years
- Endoscopic retrograde cholangiopancreatography (ERCP) to evaluate adenomas of the common bile duct
- Small-bowel imaging when duodenal adenomas are detected
- Annual physical examination for extraintestinal manifestations and thyroid abnormalities
References
- ↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). "The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes". Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.