Small cell carcinoma of the lung physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-in-Chief: Guillermo Rodriguez Nava, M.D. [2]
Overview
Many authors have concluded that performing a complete assessment, with a detailed history and physical examination, is useful for identifying patients with a higher likelihood of metastases. Fever is reported in 20% of the patients. Patient may present with weight loss, cachexia and anorexia. Upon auscultation unilateral decreased air entry, unilateral wheeze, and decreased air entry in the bases of the lungs and/or crackles (suggestive of pleural effusion) may be present. The musculoskeletal system may show the signs of Digital clubbing, Bone tenderness, (suggestive of bone metastasis) and Osteoarthropathy may be noted.
Physical Examination
The physical examination of the small cell lung cancer is described below:[1][2][3]
Vital Signs
- Fever (in up to 20% of patients with lung cancer)
- Hypertension (can be present in case of Cushing's syndrome)
General Appearance
- Cachexia (weight loss and anorexia) may be present
- Central obesity (suggestive of Cushing's syndrome) may be present
- Jaundice (suggestive of liver metastasis) may be present
- Pale skin (suggestive of anemia of chronic disease) may be present
- Cyanosis (suggestive of severe dyspnea) may be present
- Lymphadenopathy (> 1 cm) may be present
- Dehydration (suggestive of hypercalcemia) may be present
Head
- Moon facies (suggestive of Cushing's syndrome) may be present
- Swelling of the face, neck, trunk, and arms (suggestive of superior vena cava syndrome) may be present
Eyes
- Yellow discoloration of the sclera (suggestive of jaundice due to liver metastasis) may be present
- Conjunctival pallor (suggestive of anemia of chronic disease) may be present
- Miosis, ipsilateral ptosis and lack of facial sweating (suggestive of Horner's syndrome) may be present
Throat
- Hoarseness ( suggestive of compression of the recurrent laryngeal nerve) may be present
Lungs
- Unilateral decreased air entry may be present
- Unilateral wheeze may be present
- Decreased air entry in the bases of the lungs and/or crackles (suggestive of pleural effusion) may be present
Abdomen
- Hepatomegaly (> 13 cm span) (suggestive of liver metastasis) may be present
Musculoskeletal system
- Digital clubbing may be present
- Bone tenderness (suggestive of bone metastasis) may be present
- Osteoarthropathy may be present: painful symmetrical arthropathy of the knees, wrist and new periosteal bone formation.
Neurological
- Weakness of the proximal muscles of lower extremities, abnormal gait, autonomic dysfunction, and paresthesia (suggestive of Lambert-Eaton syndrome) may be present[1]
- Altered mental status, seizures, memory loss, space and time disorientation, with or without dementia (suggestive of limbic encephalitis and encephalomyelitis) may occur[1]
- Ataxia, dysarthria, severe vertigo (suggestive of paraneoplastic cerebellar degeneration) may occur[1]
- Focal neurologic signs, seizures, confusion, and personality changes (suggestive of brain metastasis)
Skin
- Acquired tylosis may be present
- Tripe palms may be present[4]
- Erythema gyratum repens (rare)
References
- ↑ 1.0 1.1 1.2 1.3 van Meerbeeck JP, Fennell DA, De Ruysscher DK (2011). "Small-cell lung cancer". Lancet. 378 (9804): 1741–55. doi:10.1016/S0140-6736(11)60165-7. PMID 21565397.
- ↑ Sher T, Dy GK, Adjei AA (2008). "Small cell lung cancer". Mayo Clin Proc. 83 (3): 355–67. doi:10.4065/83.3.355. PMID 18316005.
- ↑ Spiro SG, Gould MK, Colice GL (September 2007). "Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition)". Chest. 132 (3 Suppl): 149S–160S. doi:10.1378/chest.07-1358. PMID 17873166.
- ↑ Mullans EA, Cohen PR (1996). "Tripe palms: a cutaneous paraneoplastic syndrome". South Med J. 89 (6): 626–7. PMID 8638207.