Microangiopathic hemolytic anemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

Blood Tests

Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include:

=Complete Blood Count

• Normochromic normocytic anemia
• Thrombocytopenia usually significant with platelet count less than 20,000/μL.
• High reticulocyte count
• Raised red ce distribution width
• Raised mean platelet volume

Peripheral Blood Smear

• As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes.
• Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.