Acute megakaryoblastic leukemia overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.[1]
This rare subtype of acute myeloid leukemia (AML) was first reported in 1931 by Von Boros and his colleagues.[2]
It is classified under M7 in the French-American-British classification.[3] Subsequently, it was introduced in the WHO 2008 classification of myeloid neoplasms and acute leukemia.[4]
In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Down syndrome.[5]
References
- ↑ "Final Diagnosis -- Case 439". Retrieved 2008-03-08.
- ↑ Oki, Yasuhiro; Kantarjian, Hagop M.; Zhou, Xian; Cortes, Jorge; Faderl, Stefan; Verstovsek, Srdan; O'Brien, Susan; Koller, Charles; Beran, Miloslav; Bekele, B. Nebiyou; Pierce, Sherry; Thomas, Deborah; Ravandi, Farhad; Wierda, William G.; Giles, Francis; Ferrajoli, Alessandra; Jabbour, Elias; Keating, Michael J.; Bueso-Ramos, Carlos E.; Estey, Elihu; Garcia-Manero, Guillermo (2006). "Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center". Blood. 107 (3): 880–884. doi:10.1182/blood-2005-06-2450. ISSN 0006-4971.
- ↑ Bennett, John M. (1985). "Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)". Annals of Internal Medicine. 103 (3): 460. doi:10.7326/0003-4819-103-3-460. ISSN 0003-4819.
- ↑ Vardiman, James W.; Thiele, Jüergen; Arber, Daniel A.; Brunning, Richard D.; Borowitz, Michael J.; Porwit, Anna; Harris, Nancy Lee; Le Beau, Michelle M.; Hellström-Lindberg, Eva; Tefferi, Ayalew; Bloomfield, Clara D. (2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes". Blood. 114 (5): 937–951. doi:10.1182/blood-2009-03-209262. ISSN 0006-4971.
- ↑ Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965.