Haff disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
Haff disease has an incubation period of eight hours, and presents with nausea, vomiting, muscle rigidity, chest pain, diaphoresis, and brown urine. Though it is a self limiting condition with good prognosis, some cases may develop complication such as acute kidney injury, and disseminated intravascular coagulation.
Natural history, Complications and Prognosis
As Haff disease is a rare clinical syndrome, it is oftentimes misdiagnosed. Early diagnosis and treatment are required to prevent the development of complications.
It has an incubation period of eight hours, and presents with nausea, vomiting, myalgias, muscle rigidity, chest pain (mimicking myocardial infarction), diaphoresis, dyspnea, and brown urine indicating myoglobinuria. As it is a self limiting condition with good prognosis, most patients recover in 2-5 days. Haff disease is rarely associated with mortality, but some cases may develop complications such as acute kidney injury, and disseminated intravascular coagulation. [1] [2]