B-cell lymphoma diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
Diagnostic Study of Choice
Study of choice
B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas.
- Excisional lymph node biopsy is the gold standard test for the diagnosis of B-cell lymphomas. It is the preferred method to protect the architecture of lymph nodes, which is crucial for pathological evaluation and classification of lymphoma.[1][2][3][4]
- Fine-needle aspiration or core-needle biopsy specimens are usually insufficien because they have a low ratio of malignant cells and they do not sufficiently preserve the architecture of lymph nodes.
- Diagnostic studies of B-cell lymphomas include light microscopic evaluation of pathologic sample, as well as an immunophenotypic analysis with immunohistochemistry to determine the subtype.
Diagnostic results
- The following findings on performing pathological evaluation are confirmatory for Hodgkin's lypmhoma:[4]
- Reed-Sternberg cells (RS)
- Lymphocyte predominant cells (LP)
- The following findings on immunophenotypic analysis are confirmatory for the following types of non-Hodgkin's lypmhoma:[5][2]
- MYC-IGH rearrangement detected by FISH in the presence of a BCL2 negative germinal centres phenotype is definitive for the diagnosis of Burkitt lymphoma.
- A disrupted structure of follicle center by sheets of large cells which are positive for pan-B-cell antigens (e.g., CD20, CD79a) is definitive for the diagnosis of diffuse large B-cell lymphoma (DLBCL).[6]
- A chromosomal translocation t(11:14) is definitive for the diagnosis of mantle cell lymphoma.[7]
References
- ↑ Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL (July 2020). "Hodgkin lymphoma". Nat Rev Dis Primers. 6 (1): 61. doi:10.1038/s41572-020-0189-6. PMID 32703953 Check
|pmid=value (help). - ↑ 2.0 2.1 . PMID 27466666. Missing or empty
|title=(help) - ↑ Jiang M, Bennani NN, Feldman AL (May 2017). "Lymphoma classification update: B-cell non-Hodgkin lymphomas". Expert Rev Hematol. 10 (5): 405–415. doi:10.1080/17474086.2017.1318053. PMID 28395545.
- ↑ 4.0 4.1 Kaseb H, Babiker HM. PMID 29763144. Missing or empty
|title=(help) - ↑ Sapkota S, Shaikh H. PMID 32644754 Check
|pmid=value (help). Missing or empty|title=(help) - ↑ Liu Y, Barta SK (May 2019). "Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment". Am J Hematol. 94 (5): 604–616. doi:10.1002/ajh.25460. PMID 30859597.
- ↑ Vose JM (August 2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". Am J Hematol. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667.