B-cell lymphoma physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D [2]

Overview

Common physical examination findings of B cell lymphomas include peripheral lymphadenopathy, central lymphadenopathy, fever, pruritus, pallor, petechiae, jaundice, chest tenderness, abdominal distension, abdominal tenderness, hepatosplenomegaly.

Physical Examination

The following physical examination findings may be present among patients with B cell lymphomas:^[1]^[2]^[3]^[4]^[5]

Appearance of the Patient

Appearance of the Patients with B cell lymphomas depends on the stage of disease. Patients may present with cachexia in late disease stage.

Vital Signs

Fever
Tachypnea
Asymmetric pulse

Skin

Skin examination of patients with B cell lymphomas include:
- Pallor
- Pruritus
- Petechiae
- Jaundice

HEENT

Abnormalities of the head/hair may include:
- Icteric sclera
- Nystagmus
Patients may develop superior vena cava syndrome, which may present with:
- Swelling of the face
- Facial flushing/redness face or cheeks
- Facial tenderness
- Drooping eyelid
- Swelling around the eye

Neck

Cervical lymphadenopathy

Lungs

Thoracic masses suggestive of central lymphadenopathy
Chest tenderness
Pleural effusion may develop, which has signs and symptoms such as:
- Wheezing
- Decreased breath sounds
- Asymmetric chest expansion
- Hyperresonance lungs on chest auscultation

Heart

Cardiovascular examination of patients with B cell lymphomas is usually normal.

Abdomen

Abdominal examination of patients with B cell lymphomas include:
- Abdominal distension
- Abdominal tenderness
- Hepatosplenomegaly
- Abdominal masses suggestive of central lymphadenopathy

Back

Back examination of patients with B cell lymphomas is usually normal.

Genitourinary

Genitourinary examination of patients with B cell lymphomas is usually normal.

Neuromuscular

Neuromuscular examination of patients with B cell lymphomas is usually normal.

Extremities

CNS

Seizures

References

↑ "StatPearls". 2022. PMID 32644754 Check |pmid= value (help).
↑ "StatPearls". 2022. PMID 29763144.
↑ Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.
↑ Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (2017). "Non-Hodgkin lymphoma". Lancet. 390 (10091): 298–310. doi:10.1016/S0140-6736(16)32407-2. PMID 28153383.
↑ Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH; et al. (2020). "Hodgkin lymphoma". Nat Rev Dis Primers. 6 (1): 61. doi:10.1038/s41572-020-0189-6. PMID 32703953 Check |pmid= value (help).

Template:WikiDoc Sources

[pmid32644754-1] "StatPearls". 2022. PMID 32644754 Check |pmid= value (help).

[pmid29763144-2] "StatPearls". 2022. PMID 29763144.

[pmid19999217-3] Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.

[pmid28153383-4] Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (2017). "Non-Hodgkin lymphoma". Lancet. 390 (10091): 298–310. doi:10.1016/S0140-6736(16)32407-2. PMID 28153383.

[pmid32703953-5] Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH; et al. (2020). "Hodgkin lymphoma". Nat Rev Dis Primers. 6 (1): 61. doi:10.1038/s41572-020-0189-6. PMID 32703953 Check |pmid= value (help).

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