Hypersensitivity pneumonitis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathologic Findings
Acute HP
There are noncaseating interstitial granulomas and mononuclear cell infiltration in a peribronchial distribution. Giant cells are prominent.
Subacute or intermittent HP
The noncaseating granulomas are more well formed. There is bronchiolitis with or without organizing pneumonia. Interstitial fibrosis is present.
Chronic HP
There is chronic interstitial inflammation and alveolar destruction (honeycombing). There is dense fibrosis. The pathologic findings of chronic HP that are often associated with a poorer prognosis include the following 3 patterns of fibrosis:
- Predominantly peripheral fibrosis: in a patchy pattern with architectural distortion and fibroblast foci similar to usual interstitial pneumonia (UIP)
- Homogeneous linear fibrosis: similar to fibrotic nonspecific interstitial pneumonia (NSIP)
- Irregular predominantly peribronchiolar fibrosis
Pathophysiology of Immune Response
Exposure results in the development of circulating immunoglobulin G antibodies that are specific for the offending antigen. This antibody that forms is called the precipitating antibody, and it reacts with the specific putative antigen to form a precipitant. Initially the disease process was thought to be immunecomplex-mediated. However, subsequent studies have demonstrated that cell-mediated immunity is more important.
In the acute phase, there is a local increase in neutrophils in the alveoli and small airways. This is followed by an influx of mononuclear cells which release proteolytic enzymes, prostaglandins, and leukotrienes.
Natural History
- In general, the majority of patients recover completely after the inciting exposure ceases.
- The prognosis of Bird Fancier's Disease is worse than Farmer's Lung.
- Other varieties of HP have more variable outcomes.