Aplastic anemia pathophysiology

Aplastic anemia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Aplastic anemia is a fatal disorder in which bone marrow's myeloid progenitor cells and stem cells are severely decreased or absent. This may be seen because of either an intrinsic defect of the stem cells or immune-mediated stem cell destruction. As a result of hypocellular stem cells, transfusion-dependent anemia, thrombocytopenia, and severe neutropenia are seen associated with aplastic anemia.