Liposarcoma natural history
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
Natural History
- The natural history of liposarcoma would depend on the histopathological subtype and location.
- Liposarcomas may remain asymptomatic for a long time, specially if they are located in the retroperitoneum.
- Retroperitoneal liposarcomas may remain asymtomatic for many years (5-10 years), compared to liposarcomas in the extremities. [1]
- The common presentation for a liposarcoma located in the extremities is a painless growing mass without additional symptoms.
- The lower extremities are the most common location of liposarcomas. [1]
- Between 10 and 15% of patients may present with pain in the affected region. [1]
- Retroperitoneal liposarcomas may present as a dull abdominal pain, weight loss and abdominal distention.[2]
Complications
- Liposarcoma may cause metastasis to other organs and the lung is the most common location for metastatic disease.
Prognosis
- The prognosis of liposarcoma will depend on the histopathological subtype.
- Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this subtype is better than for other subtypes of liposarcoma.[1]
- The pleomorphic liposarcoma has a high metastasis potential and a high recurrence. The 5-year disease free survival rate for pleomorphic liposarcoma is 40%.[3]
- The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
- ↑ E. Y. Ki, S. T. Park, J. S. Park & S. Y. Hur (2012). "A huge retroperitoneal liposarcoma: case report". European journal of gynaecological oncology. 33 (3): 318–320. PMID 22873110.
- ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter
|month=ignored (help) - ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter
|month=ignored (help)