Liposarcoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Risk factors

Liposarcoma is associated with a number of risk factors. Few of them are listed below.

Chemical carcinogens

• Phenoxyacetic herbicides
• Chlorophenols
• Dioxin contaminations

Radiation

Post irradiation sarcoma has an incidence of 1%. Risk has been found with adjuvant therapy of radiation for breast carcinoma. Risk increases with dose and a dose of 50 GY or more of radiation has been recorded with increased risk of sarcoma. The mean period between exposure to radiation and tumor diagnosis is 10 years.

Immunodeficiency

Regional acquired immunodeficiency is sometimes associated with liposarcoma

Genetic susceptibility

Li-Fraumeni syndrome is associated with liposarcoma