VIPoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pathophysiology
VIPoma causes cells in the pancreas to produce high levels of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines and relaxes some of the smooth muscles in the GI system.
These pancreatic tumors secrete excessive amounts of VIP (Vasoactive Intestinal Peptide), a structural homologue of secretin. Elevated serum VIP levels cause increased intestinal secretion of Na+, K+, HCO3 -, and Cl-, as well as bone resorption, vasodilation, and inhibition of gastric acid section.[1]
References
- ↑ Joyce, David L; Hong, Kelvin; Fishman, Elliot K; Wisell, Joshua; Pawlik, Timothy M (2008). "Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension". World Journal of Surgical Oncology. 6 (1): 80. doi:10.1186/1477-7819-6-80. ISSN 1477-7819.