Mast cell leukemia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, immunohistochemistry, and flow cytometry.
Mast cell leukemia laboratory findings
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, immunohistochemistry, and flow cytometry.[1]
Complete Blood Count
On complete blood count, characteristic findings of mast cell leukemia include:[1][2]
- Bicytopenia
- Anemia
- Thrombocytopenia
- Leukopenia
- Neutropenia
Biochemistry
Total serum tryptase level is elevated in mast cell leukemia.[3]
Immunohistochemistry
On immunohistochemistry, characteristic findings of mast cell leukemia include:[1][2]
- Leukemic mast cells strongly express:
- CD13
- CD33
- CD68
- CD117
- Abnormal mast cells ususally express:[2]
- CD2
- CD25
- Other cell surface markers expressed by mast cells are:[2]
- CD11c
- CD29
- CD44
- CD45
- CD63
- CD71
- CD2
- CD22
- CD54
Flow Cytometry
- Malignant mast cells overexpress the anti-apoptosis gene, bcl-2.[3]
References
- ↑ 1.0 1.1 1.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 2.0 2.1 2.2 2.3 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 3.0 3.1 Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015