Esthesioneuroblastoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Pathophysiology

Olfactory neuroblastomas are of neural crest cell origin 1. They are mulilobulated pink-grey tumors. Histology demonstrates variable differentiation, from well formed neural tissue to undifferentiated neuroblasts with pseudorosette formation 2. It has been suggested that olfactory neuroblastoma is actually part of the Ewing sarcoma group of tumors, rather than being related to neuroblastoma.

Associated Conditions

• Associated with Trisomy 8.