Uveitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]
Overview
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes.[1][2][3][4][5]
Laboratory findings
There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes. Routine laboratory studies should be correlated with a carefully collected history and a precise physical examination. Routine laboratory tests that may be ordered and their respective findings include:[1][2][3][4][5]
Complete Blood Count with Differentials and Peripheral Blood Smear
- A low hemoglobin or hematocrit with microcytosi or marginal normocytosis may be indicative of blood loss by inflammatory bowel disease, or any chronic inflammatory disorder.
- Eosinophilia may be suggestive of underlying parasitic infections, or sarcoidosis.
- Elevated white blood cells with a left shift may be suggestive of an underlying infection.
- Decreased white blood cell count may be indicative of an immunosuppressed state.
ESR and CRP
Iron studies
- Low ferritin with a high TIBC is suggestive of chronic blood loss by inflammatory bowel disease.
- High ferritin may be suggestive of anemia of chronic inflammatory conditions.
Complete Metabolic Panel
- Elevated BUN or Cr may be suggestive of renal dysfunction in tubulointerstitial nephritis with uveitis (TINU) syndrome.
- Liver function tests such as AST or ALT may be elevated if sarcoidosis, miliary tuberculosis, or Behcet's disease affect the liver
Serology tests
- HLA subtyping: HLA-B27, HLA-A29, HLA-B9, HLA-B15
- Antinuclear antibody (ANA)
- Anti-neutrophil cytoplasmic antibody (ANCA)
- Anti-dsDNA
- Toxoplasma or Toxocara IgG or IgM
- Venereal disease research laboratory (VDRL) or Rapid Plasma Reagin (RPR) for syphilis
- Purified protein derivative (PPD) for tuberculosis
- Lyme titer
- HIV test
Other Laboratory Findings
- Elevated levels of vitamin D or angiotensin converting enzyme (ACE) are suggestive of sarcoidosis
References
- ↑ 1.0 1.1 Majumder PD, Sudharshan S, Biswas J (2013). "Laboratory support in the diagnosis of uveitis". Indian J Ophthalmol. 61 (6): 269–76. doi:10.4103/0301-4738.114095. PMC 3744779. PMID 23803478.
- ↑ 2.0 2.1 Agrawal RV, Murthy S, Sangwan V, Biswas J (2010). "Current approach in diagnosis and management of anterior uveitis". Indian J Ophthalmol. 58 (1): 11–9. doi:10.4103/0301-4738.58468. PMC 2841369. PMID 20029142.
- ↑ 3.0 3.1 Rathinam SR, Babu M (2013). "Algorithmic approach in the diagnosis of uveitis". Indian J Ophthalmol. 61 (6): 255–62. doi:10.4103/0301-4738.114092. PMC 3744777. PMID 23803476.
- ↑ 4.0 4.1 Herbort CP (2009). "Appraisal, work-up and diagnosis of anterior uveitis: a practical approach". Middle East Afr J Ophthalmol. 16 (4): 159–67. doi:10.4103/0974-9233.58416. PMC 2855658. PMID 20404984.
- ↑ 5.0 5.1 Kijlstra A (1990). "The value of laboratory testing in uveitis". Eye (Lond). 4 ( Pt 5): 732–6. doi:10.1038/eye.1990.104. PMID 2178095.