Goodpasture syndrome risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, genetic, and viral. However, we don't known what causes the antibodies to form.
Risk Factors
Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, genetic, and viral. However, we don't known what causes the antibodies to form. Certain studies suggest that infections viral or bacterial may play a role through molecular mimicry. Other associated factors that are possibly linked with initiating the disease are occupational factors, environmental factors, and behavioral factors. An example of such possibly associated factors are: smoking, using cocaine, being exposed to solvents such as formaldehyde and hydrocarbons. Genetically, the presence of allele HLA DRB1-1501 is strongly correlated to the disease.[1] This allele HLA DRB1-1501 is present in over 80% of patients would Goodpasture syndrome. Is also suggestive that the disease may be initiated following a viral or bacterial infection, however
References
- ↑ Zhao J, Cui Z, Yang R, Jia XY, Zhang Y, Zhao MH (2009). "Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity". Kidney Int. 76 (10): 1108–15. doi:10.1038/ki.2009.348. PMID 19741587.