Goodpasture syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
There are no known direct causes for Goodpasture syndrome. Common risk factors for Goodpasture syndrome are viral or bacterial infections and certain environmental and behavioral risk factors such as smoking, hydrocarbons, formaldehyde and cocaine use.[1]
Causes
Goodpasture syndrome may be caused by either viral or bacterial infections, occupational, environmental or behavioral risk factors.
Viral and bacterial risk factors causing Goodpasture syndrome
It is not clear how bacterial or viral infections play a role in Goodpasture syndrome. However, it is presumed that infections such as the influenza virus may play a role in the disease because of cross-reactivity in the basement membrane.[2]
Occupational, Environmental and Behavioral risk factors causing Goodpasture syndrome[1] [3]
Occupational, environmental and behavioral risk factors that cause Goodpasture syndrome include:
- Smoking tobacco
- Exposure to organic solvents
- Exposure to hydrocarbons
- Cocaine
- Silicosis
- Mineral dust
- D-penicillamine
References
- ↑ 1.0 1.1 Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
- ↑ Wilson CB, Dixon FJ (1973). "Anti-glomerular basement membrane antibody-induced glomerulonephritis". Kidney Int. 3 (2): 74–89. PMID 4571918.
- ↑ Bal A, Das A, Gupta D, Garg M (2014). "Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association". Case Rep Pulmonol. 2014: 398238. doi:10.1155/2014/398238. PMC 4202243. PMID 25349763.