Nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2
File:PBB Protein NCOR2 image.jpg PDB rendering based on 1xc5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xc5​
Identifiers
Symbols	NCOR2 ; CTG26; TNRC14; TRAC1; SMRT; SMRTE; SMRTE-tau; TRAC-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31370
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NCOR2 207760 s at tn.png
File:PBB GE NCOR2 208888 s at tn.png
File:PBB GE NCOR2 208889 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

NCOA2 is also sometimes referred to as silencing mediator for retinoid and thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).

External links

• nuclear+receptor+corepressor+2 at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Hörlein AJ, Näär AM, Heinzel T; et al. (1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
• Sande S, Privalsky ML (1997). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Mol. Endocrinol. 10 (7): 813–25. PMID 8813722.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Margolis RL, Abraham MR, Gatchell SB; et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114–22. PMID 9225980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong SH, David G, Wong CW; et al. (1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. PMID 9256429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Lin RJ, Schiltz RL; et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. PMID 9267036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin RJ, Nagy L, Inoue S; et al. (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laherty CD, Billin AN, Lavinsky RM; et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell. 2 (1): 33–42. PMID 9702189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Takeshita A, Misiti S; et al. (1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. PMID 9751500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong CW, Privalsky ML (1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. PMID 9765306.
• Ordentlich P, Downes M, Xie W; et al. (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. PMID 10077563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park EJ, Schroen DJ, Yang M; et al. (1999). "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3519–24. PMID 10097068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen TA, Hoivik D, Lee JE, Safe S (1999). "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex". Arch. Biochem. Biophys. 367 (2): 250–7. doi:10.1006/abbi.1999.1282. PMID 10395741.CS1 maint: Multiple names: authors list (link)
• Bailey P, Downes M, Lau P; et al. (1999). "The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD". Mol. Endocrinol. 13 (7): 1155–68. PMID 10406466.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao HY, Downes M, Ordentlich P, Evans RM (2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes Dev. 14 (1): 55–66. PMID 10640276.CS1 maint: Multiple names: authors list (link)
• Zhou S, Fujimuro M, Hsieh JJ; et al. (2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Mol. Cell. Biol. 20 (7): 2400–10. PMID 10713164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SK, Kim JH, Lee YC; et al. (2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. Biol. Chem. 275 (17): 12470–4. PMID 10777532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guenther MG, Lane WS, Fischle W; et al. (2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. PMID 10809664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grozinger CM, Schreiber SL (2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMID 10869435.