PELP-1
| proline, glutamic acid and leucine rich protein 1 | |
|---|---|
| Identifiers | |
| Symbol | PELP1 |
| Entrez | 27043 |
| HUGO | 30134 |
| OMIM | 609455 |
| RefSeq | NM_014389 |
| UniProt | Q8IZL8 |
| Other data | |
| Locus | Chr. 17 p13.2 |
PELP-1 (MNAR)[1] is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors[2] and a coactivator for estrogen receptors.[3]
Activation of protein kinases
PELP-1 has been shown to bind to both estrogen receptor alpha and estrogen receptor beta.[4] It was also reported that protein tyrosine kinases of the src family can form a complex with estrogen receptors and PELP-1 and it was reported that when bound to PELP-1 and estrogen receptor alpha the kinase activity of SRC was activated in an estrogen-sensitive manner. Mitogen-activated protein kinases ERK1 and ERK2 were found to become phosphorylated in estrogen-treated cells containing PELP-1 . It was reported that the enhancement of estrogen-induced gene transcription due to PELP-1 could be blocked by protein kinase inhibitors. This suggested a model of PELP-1 function in which estrogen and PELP-1 cooperate to activate protein kinases which in turn activate gene transcription.[4]
Histone deacetylase
When functioning as a corepressor of transcription PELP-1 recruits histone deacetylase.[2] Estrogen has been associated with stimulation of cell proliferation and progression of cells through G1 to the S phase of the cell cycle. The retinoblastoma protein (Rb) is a regulator of G1. It was reported that PELP-1 interacts with Rb.[5] It is not known if estrogen receptors can displace histone deacetylase from Rb.
See also
References
- ↑ Vadlamudi RK, Kumar R (2007). "Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR". Nuclear receptor signaling. 5: e004. doi:10.1621/nrs.05004. PMID 17525794.
- ↑ 2.0 2.1 Y. B. Choi, J. K. Ko and J. Shin (2004) "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains" in Journal of Biological Chemistry Volume 279, pages 50930-50941. Template:Entrez Pubmed
- ↑ R. K. Vadlamudi, R. A. Wang, A. Mazumdar, Y. Kim, J. Shin, A. Sahin and R. Kumar (2001) "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha" in Journal of Biological Chemistry Volume 276, pages 38272-38279. Template:Entrez Pubmed
- ↑ 4.0 4.1 C. W. Wong, C. McNally, E. Nickbarg, B. S. Komm and B. J. Cheskis (2002) "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade" in Proceedings of the National Academy of Sciences of the United States of America Volume 99, pages 14783-14788. Template:Entrez Pubmed
- ↑ S. Balasenthil and R. K. Vadlamudi (2003) "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein" in Journal of Biological Chemistry Volume 278, pages 22119-22127. Template:Entrez Pubmed
External links
- PELP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)