Nuclear receptor coactivator 3

Nuclear receptor coactivator 3
File:PBB Protein NCOA3 image.jpg PDB rendering based on 1kbh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kbh​
Identifiers
Symbols	NCOA3 ; RAC3; ACTR; AIB-1; AIB1; CAGH16; CTG26; MGC141848; SRC-1; SRC3; TNRC14; TNRC16; TRAM-1; pCIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4764
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NCOA3 207700 s at tn.png
File:PBB GE NCOA3 209060 x at tn.png
File:PBB GE NCOA3 209062 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The nuclear receptor coactivator 3 (NCOA3) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA3 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA3 assists nuclear receptors in the upregulation of gene expression.

NCOA3 is also frequently called amplified in breast 1 (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Further reading

• Liao L, Kuang SQ, Yuan Y; et al. (2003). "Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1". J. Steroid Biochem. Mol. Biol. 83 (1–5): 3–14. PMID 12650696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell. Biol. 15 (7): 3479–86. PMID 7791754.CS1 maint: Multiple names: authors list (link)
• Guan XY, Xu J, Anzick SL; et al. (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50. PMID 8758910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Margolis RL, Abraham MR, Gatchell SB; et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114–22. PMID 9225980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Gomes PJ, Chen JD (1997). "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8479–84. PMID 9238002.CS1 maint: Multiple names: authors list (link)
• Anzick SL, Kononen J, Walker RL; et al. (1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science. 277 (5328): 965–8. PMID 9252329.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Lin RJ, Schiltz RL; et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. PMID 9267036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeshita A, Cardona GR, Koibuchi N; et al. (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J. Biol. Chem. 272 (44): 27629–34. PMID 9346901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Korzus E, Torchia J, Rose DW; et al. (1998). "Transcription factor-specific requirements for coactivators and their acetyltransferase functions". Science. 279 (5351): 703–7. PMID 9445475.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shirazi SK, Bober MA, Coetzee GA (1998). "Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene)". Clin. Genet. 54 (1): 102–3. PMID 9727751.CS1 maint: Multiple names: authors list (link)
• Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. Chem. 273 (47): 30847–50. PMID 9812974.CS1 maint: Multiple names: authors list (link)
• Zwijsen RM, Buckle RS, Hijmans EM; et al. (1999). "Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1". Genes Dev. 12 (22): 3488–98. PMID 9832502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Lin RJ, Xie W; et al. (1999). "Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase". Cell. 98 (5): 675–86. PMID 10490106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ebisawa T, Tada K, Kitajima I; et al. (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell. Sci. 112 ( Pt 20): 3519–27. PMID 10504300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie W, Hong H, Yang NN; et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Mol. Endocrinol. 13 (12): 2151–62. PMID 10598588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pao GM, Janknecht R, Ruffner H; et al. (2000). "CBP/p300 interact with and function as transcriptional coactivators of BRCA1". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1020–5. PMID 10655477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leo C, Li H, Chen JD (2000). "Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3". J. Biol. Chem. 275 (8): 5976–82. PMID 10681591.CS1 maint: Multiple names: authors list (link)
• Font de Mora J, Brown M (2000). "AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor". Mol. Cell. Biol. 20 (14): 5041–7. PMID 10866661.
• Tan JA, Hall SH, Petrusz P, French FS (2000). "Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator". Endocrinology. 141 (9): 3440–50. PMID 10965917.CS1 maint: Multiple names: authors list (link)

External links

• nuclear+receptor+coactivator+3 at the US National Library of Medicine Medical Subject Headings (MeSH)