GNAQ

Guanine nucleotide binding protein (G protein), q polypeptide
PDB rendering based on 2bcj.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bcj​
Identifiers
Symbols	GNAQ ; G-ALPHA-q; GAQ
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1566
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Guanine nucleotide binding protein (G protein), q polypeptide, also known as GNAQ, is a human gene.

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]

Further reading

• Raymond JR, Mukhin YV, Gelasco A; et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. PMID 11916537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Oekelen D, Luyten WH, Leysen JE (2003). "5-HT2A and 5-HT2C receptors and their atypical regulation properties". Life Sci. 72 (22): 2429–49. PMID 12650852.CS1 maint: Multiple names: authors list (link)
• Lesch KP, Manji HK (1992). "Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain". Biol. Psychiatry. 32 (7): 549–79. PMID 1333286.
• Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312 ( Pt 1): 151–8. PMID 7492305.CS1 maint: Multiple names: authors list (link)
• Blin N, Yun J, Wess J (1995). "Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor". J. Biol. Chem. 270 (30): 17741–8. PMID 7629074.CS1 maint: Multiple names: authors list (link)
• Kabouridis PS, Waters ST, Escobar S; et al. (1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol. Cell. Biochem. 144 (1): 45–51. PMID 7791744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allgeier A, Offermanns S, Van Sande J; et al. (1994). "The human thyrotropin receptor activates G-proteins Gs and Gq/11". J. Biol. Chem. 269 (19): 13733–5. PMID 8188646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wedegaertner PB, Chu DH, Wilson PT; et al. (1993). "Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha". J. Biol. Chem. 268 (33): 25001–8. PMID 8227063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology. 132 (6): 2484–90. PMID 8504751.CS1 maint: Multiple names: authors list (link)
• Laugwitz KL, Allgeier A, Offermanns S; et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. PMID 8552586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denker SP, McCaffery JM, Palade GE; et al. (1996). "Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas". J. Cell Biol. 133 (5): 1027–40. PMID 8655576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen B, Leverette RD, Schwinn DA, Kwatra MM (1996). "Human G(alpha q): cDNA and tissue distribution". Biochim. Biophys. Acta. 1281 (2): 125–8. PMID 8664309.CS1 maint: Multiple names: authors list (link)
• Dong Q, Shenker A, Way J; et al. (1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene". Genomics. 30 (3): 470–75. doi:10.1006/geno.1995.1267. PMID 8825633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318 ( Pt 3): 1023–31. PMID 8836152.CS1 maint: Multiple names: authors list (link)
• Gomeza J, Mary S, Brabet I; et al. (1996). "Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists". Mol. Pharmacol. 50 (4): 923–30. PMID 8863838.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta". J. Soc. Gynecol. Investig. 3 (6): 316–21. PMID 8923415.CS1 maint: Multiple names: authors list (link)
• Petit A, Geoffroy P, Bélisle S (1997). "Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension". Life Sci. 60 (12): 953–60. PMID 9061052.CS1 maint: Multiple names: authors list (link)
• Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.CS1 maint: Multiple names: authors list (link)
• Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. PMID 9175863.CS1 maint: Multiple names: authors list (link)
• Gabbeta J, Yang X, Kowalska MA; et al. (1997). "Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8750–5. PMID 9238049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)