GRIA3

Glutamate receptor, ionotrophic, AMPA 3
Identifiers
Symbols	GRIA3 ; GLUR-K3; GLUR3; GLURC; gluR-C
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37353
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, ionotrophic, AMPA 3, also known as GRIA3, is a human gene.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternative splicing at this locus results in several different isoforms which may vary in their signal transduction properties.

See also

• AMPA receptor

Further reading

• McNamara JO, Eubanks JH, McPherson JD; et al. (1992). "Chromosomal localization of human glutamate receptor genes". J. Neurosci. 12 (7): 2555–62. PMID 1319477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hollmann M, Hartley M, Heinemann S (1991). "Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition". Science. 252 (5007): 851–3. PMID 1709304.CS1 maint: Multiple names: authors list (link)
• Rampersad V, Elliott CE, Nutt SL; et al. (1994). "Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins". Biochim. Biophys. Acta. 1219 (2): 563–6. PMID 7918660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rogers SW, Andrews PI, Gahring LC; et al. (1994). "Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis". Science. 265 (5172): 648–51. PMID 8036512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomiyama M, Rodriguez-Puertas R, Cortés R; et al. (1997). "Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization". Neuroscience. 75 (3): 901–15. PMID 8951883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Osten P, Srivastava S, Inman GJ; et al. (1998). "The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs". Neuron. 21 (1): 99–110. PMID 9697855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava S, Osten P, Vilim FS; et al. (1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–91. PMID 9768844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayashi T, Umemori H, Mishina M, Yamamoto T (1999). "The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn". Nature. 397 (6714): 72–6. doi:10.1038/16269. PMID 9892356.CS1 maint: Multiple names: authors list (link)
• Amir R, Dahle EJ, Toriolo D, Zoghbi HY (2000). "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq". Am. J. Med. Genet. 90 (1): 69–71. PMID 10602120.CS1 maint: Multiple names: authors list (link)
• Gécz J, Barnett S, Liu J; et al. (2000). "Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation". Genomics. 62 (3): 356–68. doi:10.1006/geno.1999.6032. PMID 10644433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aruscavage PJ, Bass BL (2000). "A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing". RNA. 6 (2): 257–69. PMID 10688364.
• Gahring L, Carlson NG, Meyer EL, Rogers SW (2001). "Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation". J. Immunol. 166 (3): 1433–8. PMID 11160179.CS1 maint: Multiple names: authors list (link)
• Liu QJ, Gong YQ, Chen BX; et al. (2001). "[Linkage analysis and mutation detection of GRIA3 in Smith--Fineman--Myers syndrome]". Yi Chuan Xue Bao. 28 (11): 985–90. PMID 11725645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirbec H, Perestenko O, Nishimune A; et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wyszynski M, Kim E, Dunah AW; et al. (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. PMID 11931740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomiyama M, Rodríguez-Puertas R, Cortés R; et al. (2002). "Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis". Synapse. 45 (4): 245–9. doi:10.1002/syn.10098. PMID 12125045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ganor Y, Besser M, Ben-Zakay N; et al. (2003). "Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration". J. Immunol. 170 (8): 4362–72. PMID 12682273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flajolet M, Rakhilin S, Wang H; et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMID 14663150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolleker A, Zhu JJ, Schupp BJ; et al. (2004). "Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors". Neuron. 40 (6): 1199–212. PMID 14687553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GRIA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.