Renal amyloidosis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
If left untreated, renal amyoidosis may progress into end stage renal disease. Common complications include chronic renal failure and nephrotic syndrome.
Natural History, Complications, and Prognosis
Natural History
- If renal amyloidosis left untreated it usually manifests as nephrotic range proteinuria and then progresses to acute kidney injury and then end stage renal disease.[1]
Complications
- Common complications of renal amyloidosis include:[2][3]
- Proteinuria (32%)
- Nephrotic syndrome (40%)
- Chronic renal failure (28%)
- Hypoalbuminemia
Prognosis
- After a few years, renal amyloidosis eventually leads to end stage renal disease and it may be accelerated by some factors such as:[4]
- Steroid administration
- Renal vein thrombosis
- Infections
- Surgery
References
- ↑ Lohani S, Schuiteman E, Garg L, Yadav D, Zarouk S (2016). "Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis". Case Rep Nephrol. 2016: 8690642. doi:10.1155/2016/8690642. PMC 5093243. PMID 27840752.
- ↑ Bilginer Y, Akpolat T, Ozen S (August 2011). "Renal amyloidosis in children". Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.
- ↑ Hajra A, Bandyopadhyay D (2016). "An interesting case of renal amyloidosis". Indian J Nephrol. 26 (6): 467–469. doi:10.4103/0971-4065.177143. PMC 5131391. PMID 27942184.
- ↑ Kaaroud H, Ben Moussa F, Goucha R, Abderrahim E, Ben Hamida F, Ben Hamida F, Ben Hamida F, Kheder A, Ben Miaz H (May 1999). "Influence of surgery on renal amyloidosis". Kidney Int. 55 (5): 2117–2133. doi:10.1046/j.1523-1755.1999.00455.x. PMID 10231478.