Aplastic anemia classification

Aplastic anemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Aplastic anemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Aplastic anemia classification On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Aplastic anemia classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Aplastic anemia classification
CDC on Aplastic anemia classification
Aplastic anemia classification in the news
Blogs on Aplastic anemia classification
Directions to Hospitals Treating Aplastic anemia
Risk calculators and risk factors for Aplastic anemia classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:

• Moderately severe aplastic anemia or non severe AA (nSAA)
• Severe aplastic anemia (SAA)
• Very severe aplastic anemia(vSAA)

Classification of aplastic anemia (two out of three criteria must be met)

	nSAA	SAA	vSAA
Reticulocytes	<20G/L	<20G/L	<20G/L
Platelets	<50 G / L	<20G/L	<20G/L
Neutrophilic granulocytes	<1.0 G / L	<0.5G/L	0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

classification based on the presumed etiology

Acquired aplastic anemia
Idiopathic
Secondry	Irradiation Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold salts, NSAIDS Idiosyncratic reactions Viruses: Epstein Barr virus, parvovirus B19, HIV Immune diseases Pregnancy PNH Paroxysmal nocturnal hemoglobinuria
Inherited aplastic anemia	Fanconi anemia Dyskeratosis congenital Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome