Monoclonal gammopathy of undetermined significance differential diagnosis
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Differentiating Monoclonal gammopathy of undetermined significance from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before a formal diagnosis is made like multiple myeloma, AIDS, chronic lymphocytic leukemia, non-Hodgkin Lymphoma, particularly splenic marginal zone lymphoma and lymphoplasmocytic lymphoma.
Differentiating Monoclonal gammopathy of undetermined significance form other Diseases
Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before a formal diagnosis is made:
- Multiple myeloma
- AIDS
- Chronic lymphocytic leukemia
- Non-Hodgkin Lymphoma, particularly Splenic marginal zone lymphoma[1] and Lymphoplasmocytic lymphoma
- Hepatitis C
- Connective tissue disease such as lupus[2]
- Immunosuppression following organ tranplantation
- Waldenström macroglobulinemia
- Guillain-Barre syndrome[3]
References
- ↑ Murakami H, Irisawa H, Saitoh T, Matsushima T, Tamura J, Sawamura M, Karasawa M, Hosomura Y, Kojima M (1997). "Immunological abnormalities in splenic marginal zone cell lymphoma". Am. J. Hematol. 56 (3): 173–8. PMID 9371530.
- ↑ Larking-Pettigrew M, Ranich T, Kelly R (1999). "Rapid onset monoclonal gammopathy in cutaneous lupus erythematosus: interference with complement C3 and C4 measurement". Immunol. Invest. 28 (4): 269–76. PMID 10454004.
- ↑ Czaplinski A, Steck A (2004). "Immune mediated neuropathies--an update on therapeutic strategies". J. Neurol. 251 (2): 127–37. PMID 14991345.