Loefflers syndrome pathophysiology

Löffler's syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Loefflers syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Loefflers syndrome pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Loefflers syndrome pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Loefflers syndrome pathophysiology
CDC on Loefflers syndrome pathophysiology
Loefflers syndrome pathophysiology in the news
Blogs on Loefflers syndrome pathophysiology
Directions to Hospitals Treating Loefflers syndrome
Risk calculators and risk factors for Loefflers syndrome pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

It is understood that Löffler syndrome is the result of transpulmonary passage of helminth larvae. Helminths, with a pulmonary life cycle are responsible for this syndrome, among them are Ascaris.lumbricoides, Ascaris. suum, Ancylostoma duodenale, Necator americanus, and Strongyloides stercoralis.

Pathophysiology

Pathogenesis

• It is understood that Löffler syndrome is the result of transpulmonary passage of helminth larvae. Helminths, with a pulmonary life cycle are responsible for this syndrome, among them are Ascaris lumbricoides, Ascaris suum, Ancylostoma duodenale, Necator americanus, and Strongyloides stercoralis.
• Pathogen is usually transmitted via the oral route (Ascaris) or penetrate skin (Necator) to the human host.
• Following transmission/ingestion, infecting larvae reach the lungs via the bloodstream, penetrate into alveoli, mature, and ascend the airways before descending the alimentary tract into the small bowel
• Ascaris is the most common cause of Löffler syndrome worldwide. On the other hand, migrating larvae of hookworms (Ancylostoma duodenale, Necator americanus) and Strongyloides are less likely to elicit symptoms or pulmonary eosinophilia.

Associated Conditions

Conditions associated with [disease name] include:

• [Condition 1]
• [Condition 2]
• [Condition 3]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].