Milk-alkali syndrome primary prevention

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Overview

Primary prevention

Effective measures for the primary prevention of milk-alkali syndrome include:[1][2][3][4][5][6][7]

  • Public education about the potential adverse effects of calcium supplements due to its wide use with the awareness of osteoporosis prevention is important.
  • Calcium intake less than 2 g/daily is usually safe.2,77
  • However, 1.2 to 1.5 g/daily of calcium intake should be taken by individuals with risk factors for milk-alkali syndrome, such as elderly, preexisting chronic renal disease, concurrent vomiting (bulimia or hyperemesis of pregnancy) and use of certain drugs like thiazide, NSAIDs, and ACE inhibitors.

References

  1. Medarov BI (2009). "Milk-alkali syndrome". Mayo Clin Proc. 84 (3): 261–7. doi:10.1016/S0025-6196(11)61144-0. PMC 2664604. PMID 19252114.
  2. Beall DP, Scofield RH (1995). "Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia". Medicine (Baltimore). 74 (2): 89–96. doi:10.1097/00005792-199503000-00004. PMID 7891547.
  3. Whiting SJ, Wood R, Kim K (1997). "Calcium supplementation". J Am Acad Nurse Pract. 9 (4): 187–92. PMID 9274239.
  4. Patel AM, Goldfarb S (2010). "Got calcium? Welcome to the calcium-alkali syndrome". J Am Soc Nephrol. 21 (9): 1440–3. doi:10.1681/ASN.2010030255. PMID 20413609.
  5. Felsenfeld AJ, Levine BS (2006). "Milk alkali syndrome and the dynamics of calcium homeostasis". Clin J Am Soc Nephrol. 1 (4): 641–54. doi:10.2215/CJN.01451005. PMID 17699269.
  6. Picolos MK, Lavis VR, Orlander PR (2005). "Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients". Clin Endocrinol (Oxf). 63 (5): 566–76. doi:10.1111/j.1365-2265.2005.02383.x. PMID 16268810.
  7. Arroyo M, Fenves AZ, Emmett M (2013). "The calcium-alkali syndrome". Proc (Bayl Univ Med Cent). 26 (2): 179–81. doi:10.1080/08998280.2013.11928954. PMC 3603742. PMID 23543983.

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