Acute megakaryoblastic leukemia differential diagnosis
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Distinguishing features from other subtypes of AML are following:
- Thrombocytopenia is more common and severe in AMKL compared with myelodysplastic syndrome (MDS). Blast cells in the bone marrow are <30% in MDS versus >30% in AMKL.[1]
- Presence of megakaryocytic specific antigens (CD41, CD61)[2] and markers (glycoprotein 1b) and platelets peroxidase serology. Karyotype analysis also helpful due to its complex and unusual karyotypic presentation (t(1;22)(p13;q13).[3][4]
Differential Diagnoses:[5]
Acute myeloid leukemia otherwise not specified as per WHO classification:
- Acute myeloid leukemia with minimal differentiation
- Acute myeloid leukemia without maturation
- Acute myeloid leukemia with maturation
- Acute myelomonocytic leukemia
- Acute monoblastic/monocytic leukemia
- Acute erythroid leukemia
- Pure erythroid leukemia
- Erythroleukemia, erythroid/myeloid
- Acute basophilic leukemia
- Acute panmyelosis with myelofibrosis (a.k.a acute myelofibrosis)
Myeloid sarcoma
References
- ↑ Zipursky, A.; Thorner, P.; De Harven, E.; Christensen, H.; Doyle, J. (1994). "Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome". Leukemia Research. 18 (3): 163–171. doi:10.1016/0145-2126(94)90111-2. ISSN 0145-2126.
- ↑ O Olatunji, Philip (2018). "A case of acute megakaryoblastic leukaemia (FAB M7), a rare type of acute myeloid leukemia (AML), in a teenager". Malawi Medical Journal. 30 (4): 298. doi:10.4314/mmj.v30i4.15. ISSN 1995-7262.
- ↑ Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.
- ↑ De Marchi, Federico; Araki, Marito; Komatsu, Norio (2019). "Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia". Expert Review of Hematology. 12 (5): 285–293. doi:10.1080/17474086.2019.1609351. ISSN 1747-4086.
- ↑ Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.