Acute megakaryoblastic leukemia history and symptoms
{{Acute megakaryoblastic leukemia]}}
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
- Acute megakaryoblastic leukemia (AMKL) has a wide array of presentations. The onset is either acute or insidious. The degree of pancytopenia varies among patients.[1] Other features include fever, irritability, headache, fatigue, bone pain,[2] hepatosplenomegaly (HSM), and lymphadenopathy,[3][4] pallor, generalized pain, temporal swelling, bruising, and difficulty walking.[5]
- Greater than 50% of leukemia patients demonstrate skeletal features and are mostly related to the AMKL subtype.[6]
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References
- ↑ Zipursky A, Peeters M, Poon A (1987). "Megakaryoblastic leukemia and Down's syndrome: a review". Pediatr Hematol Oncol. 4 (3): 211–30. doi:10.3109/08880018709141272. PMID 2978961.
- ↑ Paredes-Aguilera R, Romero-Guzman L, Lopez-Santiago N, Trejo RA (2003). "Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children". Am J Hematol. 73 (2): 71–80. doi:10.1002/ajh.10320. PMID 12749007.
- ↑ Jayasudha, A. V.; Nair, Rekha A.; Jacob, Priya Mary; Renu, S.; Anila, K. R.; Sindhu Nair, P.; Priya Kumari, T.; Kusuma Kumary, P. (2014). "Clinical and Hematological Profile of Acute Megakaryoblastic Leukemia: A 2 Year Study". Indian Journal of Hematology and Blood Transfusion. 31 (2): 169–173. doi:10.1007/s12288-014-0413-1. ISSN 0971-4502.
- ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.
- ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.
- ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.