B-cell lymphoma diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]

Overview

Diagnostic Study of Choice

Study of choice

B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas.

  • Excisional lymph node biopsy is the gold standard test for the diagnosis of B-cell lymphomas. It is the preferred method to protect the architecture of lymph nodes, which is crucial for pathological evaluation and classification of lymphoma.[1][2][3][4]
  • Fine-needle aspiration or core-needle biopsy specimens are usually insufficien because they have a low ratio of malignant cells and they do not sufficiently preserve the architecture of lymph nodes.
  • Diagnostic studies of B-cell lymphomas include light microscopic evaluation of pathologic sample, as well as an immunophenotypic analysis with immunohistochemistry to determine the subtype.
Diagnostic results
  • The following findings on performing pathological evaluation are confirmatory for Hodgkin's lypmhoma:[4]
    • Reed-Sternberg cells (RS)
    • Lymphocyte predominant cells (LP)
  • The following findings on immunophenotypic analysis are confirmatory for the following types of non-Hodgkin's lypmhoma:[5]

References

  1. ↑ Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL (July 2020). "Hodgkin lymphoma". Nat Rev Dis Primers. 6 (1): 61. doi:10.1038/s41572-020-0189-6. PMID 32703953 Check |pmid= value (help).
  2. ↑ . PMID 27466666. Missing or empty |title= (help)
  3. ↑ Jiang M, Bennani NN, Feldman AL (May 2017). "Lymphoma classification update: B-cell non-Hodgkin lymphomas". Expert Rev Hematol. 10 (5): 405–415. doi:10.1080/17474086.2017.1318053. PMID 28395545.
  4. ↑ 4.0 4.1 Kaseb H, Babiker HM. PMID 29763144. Missing or empty |title= (help)
  5. ↑ Sapkota S, Shaikh H. PMID 32644754 Check |pmid= value (help). Missing or empty |title= (help)
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