Nuclear receptor coactivator 1
| Nuclear receptor coactivator 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
File:PBB Protein NCOA1 image.jpg PDB rendering based on 1oj5. | |||||||||||
| Identifiers | |||||||||||
| Symbols | NCOA1 ; SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7859 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE NCOA1 209106 at tn.png | |||||||||||
| File:PBB GE NCOA1 209105 at tn.png | |||||||||||
| File:PBB GE NCOA1 209107 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
External links
- nuclear+receptor+coactivator+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822.
- ↑ Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". J Biol Chem. 273 (20): 12101–8. doi:10.1074/jbc.273.20.12101. PMID 9575154.